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Scientific References
  • 1.

    Walker RE, Ford JL, Boston RC, Savinova OV, Harris WS, Green MH, Shearer GC. Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia. Am J Physiol Endocrinol Metab. 2020 Mar 1;318(3):E392-E404. doi: 10.1152/ajpendo.00331.2019. Epub 2020 Jan 7. PMID: 31910030; PMCID: PMC7099405.

  • 2.

    Johnston, L.W., Harris, S.B., Retnakaran, R. et al. Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort. Diabetologia 61, 821–830 (2018). https://doi.org/10.1007/s00125-017-4534-6

  • 3.

    Fredrik Karpe, Julian R. Dickmann, Keith N. Frayn; Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation. Diabetes 1 October 2011; 60 (10): 2441–2449.

  • 4.

    Steffen BT, Steffen LM, Zhou X, Ouyang P, Weir NL, Tsai MY. n-3 Fatty acids attenuate the risk of diabetes associated with elevated serum nonesterified fatty acids: the multi-ethnic study of atherosclerosis. Diabetes Care. 2015 Apr;38(4):575-80. doi: 10.2337/dc14-1919. Epub 2015 Jan 8. PMID: 25573885; PMCID: PMC4370329.

  • 5.

    Najjar, S.M.; Abdolahipour, R.; Ghadieh, H.E.; Jahromi, M.S.; Najjar, J.A.; Abuamreh, B.A.M.; Zaidi, S.; Kumarasamy, S.; Muturi, H.T. Regulation of Insulin Clearance by Non-Esterified Fatty Acids. Biomedicines 2022, 10, 1899. https://doi.org/10.3390/biomedicines10081899

  • 6.

    Grapov D, Adams SH, Pedersen TL, Garvey WT, Newman JW (2012) Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids. PLOS ONE 7(11): e48852. https://doi.org/10.1371/journal.pone.0048852

  • 7.

    Johnston, L.W., Harris, S.B., Retnakaran, R. et al. Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort. Diabetologia 61, 821–830 (2018).

  • 8.

    Ahn J, Um MY, Lee H, Jung CH, Heo SH, Ha TY. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice. Evid Based Complement Alternat Med. 2013;2013:934183. doi: 10.1155/2013/934183. Epub 2013 Apr 10. PMID: 23690865; PMCID: PMC3638629.

  • 9.

    Ríos-Silva M, Trujillo X, Trujillo-Hernández B, Sánchez-Pastor E, Urzúa Z, Mancilla E, Huerta M. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes. Int J Med Sci. 2014 Mar 11;11(5):448-52. doi: 10.7150/ijms.8034. PMID: 24688307; PMCID: PMC3970096.

  • 10.

    Chen JY, Peng SY, Cheng YH, Lee IT, Yu YH. Effect of Forskolin on Body Weight, Glucose Metabolism and Adipocyte Size of Diet-Induced Obesity in Mice. Animals (Basel). 2021 Mar 1;11(3):645. doi: 10.3390/ani11030645. PMID: 33804418; PMCID: PMC8000574.

  • 11.

    Godard, M.P., Johnson, B.A. and Richmond, S.R. (2005), Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Obesity Research, 13: 1335-1343.

  • 12.

    Henderson S, Magu B, Rasmussen C, Lancaster S, Kerksick C, Smith P, Melton C, Cowan P, Greenwood M, Earnest C, Almada A, Milnor P, Magrans T, Bowden R, Ounpraseuth S, Thomas A, Kreider RB. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J Int Soc Sports Nutr. 2005 Dec 9;2(2):54-62. doi: 10.1186/1550-2783-2-2-54. PMID: 18500958; PMCID: PMC2129145.

  • 13.

    Li A, Liu J, Ding F, Wu X, Pan C, Wang Q, Gao M, Duan S, Han X, Xia K, Liu S, Wu Y, Zhou Z, Zhang X, Gao XD. Maca extracts regulate glucose and lipid metabolism in insulin-resistant HepG2 cells via the PI3K/AKT signalling pathway. Food Sci Nutr. 2021 Mar 29;9(6):2894-2907. doi: 10.1002/fsn3.2246. PMID: 34136157; PMCID: PMC8194906.

  • 14.

    Agrawal OD, Kulkarni YA. Treatment with Terminalia chebula Extract Reduces Insulin Resistance, Hyperglycemia and Improves SIRT1 Expression in Type 2 Diabetic Rats. Life (Basel). 2023 May 11;13(5):1168. doi: 10.3390/life13051168. PMID: 37240813; PMCID: PMC10221349.

  • 15.

    El-Shamarka MEA, Aboulthana WM, Omar NI, Mahfouz MM. Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study. Inflammopharmacology. 2024 Apr;32(2):1439-1460. doi: 10.1007/s10787-024-01428-9. Epub 2024 Feb 8. PMID: 38329710; PMCID: PMC11006788.

  • 16.

    Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion. J Med Food. 2017 Aug;20(8):750-754. doi: 10.1089/jmf.2017.0001. Epub 2017 May 1. PMID: 28459647.

  • 17.

    Khan F, Sarker MMR, Ming LC, Mohamed IN, Zhao C, Sheikh BY, Tsong HF, Rashid MA. Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre. Front Pharmacol. 2019 Oct 29;10:1223. doi: 10.3389/fphar.2019.01223. PMID: 31736747; PMCID: PMC6830388.

  • 18.

    Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014;2014:830285. doi: 10.1155/2014/830285. Epub 2014 Jan 6. PMID: 24511547; PMCID: PMC3912882.

  • 19.

    Ngondi, Judith Laure, Blanche Cunégonde Omgba Etoundi, Christine B Nyangono, Carl M. F. Mbofung and Julius Enyong Oben. “Lipids in Health and Disease.” (2009).

  • 20.

    Ngondi JL, Oben JE, Minka SR. The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon. Lipids Health Dis. 2005 May 25;4:12. doi: 10.1186/1476-511X-4-12. PMID: 15916709; PMCID: PMC1168905.

  • 21.

    Ross SM. African mango (IGOB131): a proprietary seed extract of Irvingia gabonensis is found to be effective in reducing body weight and improving metabolic parameters in overweight humans. Holist Nurs Pract. 2011 Jul-Aug;25(4):215-7. doi: 10.1097/HNP.0b013e318222735a. PMID: 21697664.

  • 22.

    https://www.healthline.com/nutrition/african-mango#bottom-line

  • 23.

    Lown M, Fuller R, Lightowler H, Fraser A, Gallagher A, Stuart B, Byrne C, Lewith G. Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled study. PLoS One. 2017 Feb 22;12(2):e0172239. doi: 10.1371/journal.pone.0172239. PMID: 28225835; PMCID: PMC5321430.

  • 24.

    Yuan HD, Kim JT, Kim SH, Chung SH. Ginseng and diabetes: the evidences from in vitro, animal and human studies. J Ginseng Res. 2012 Jan;36(1):27-39. doi: 10.5142/jgr.2012.36.1.27. PMID: 23717101; PMCID: PMC3659569.

  • 25.

    Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. The therapeutic potential of milk thistle in diabetes. Rev Diabet Stud. 2014 Summer;11(2):167-74. doi: 10.1900/RDS.2014.11.167. Epub 2014 Aug 10. PMID: 25396404; PMCID: PMC4310066.

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